A cohort, double blind, and randomized study was conducted to investigate the effect of a single nucleotide polymorphism of the\r\n??-opioid receptor at nucleotide position 118 (OPRM1:c.118A>G) on the association with the most common side effects (nausea or\r\nvomiting) induced by intravenous patient control analgesia (IVPCA) with morphine, including incidence and severity analysis.\r\nA total of 129 Taiwanese women undergoing gynecology surgery received IVPCA with pure morphine for postoperative pain\r\nrelief. Blood samples were collected and sequenced with high resolution melting analysis to detect three different genotypes of\r\nOPRM1 (AA, AG, and GG). All candidates 24 h postoperatively will be interviewed to record the clinical phenotype with subjective\r\ncomplaints and objective observations. The genotyping after laboratory analysis showed that 56 women (43.4%) were AA, 57\r\n(44.2%) were AG, and 16 (12.4%) were GG. The distribution of genotype did not violate Hardy-Weinberg equilibrium test. There\r\nwas no significant difference neither between the severity and incidence of IVPCA morphine-induced side effects and genotype nor\r\nbetween the association betweenmorphine consumption versus genotype. However, there was significant difference of the relation\r\nbetween morphine consumption and the severity and incidence of IVPCA morphine-induced nausea and vomiting. The genetic\r\nanalysis for the severity and incidence of IVPCA morphine-induced nausea or vomiting showed no association between phenotype\r\nand genotype. It might imply that OPRM1:c.118A>G does not protect against IVPCA morphine-induced nausea or vomiting.
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